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Dr Colette Christiansen

Staff Tutor And Senior Lecturer In Mathematics And Statistics

School of Mathematics & Statistics

c.christiansen@open.ac.uk

Biography

Professional biography

I am a Senior Lecturer and Staff Tutor in the School of Mathematics and Statistics and I have been teaching statistics at the Open University since 2019.  I have a PhD in Epigenetics from King's College London. Prior to moving into academia I was a consulting actuary.

Research interests

My research interests are in applying mathematics and statistics to biology, particularly in the field of genetics and epigenetics.  I chair the Mathematical Biology research group and I am keen to promote interdisciplinary working.  I am also a Lead for the Open Societal Challenges research programme.

Teaching interests

My teaching interests are in statistics.  I currently teach M249 "Practical Modern Statistics" and have previously taught M140 "Introduction to Statistics".  In addition I am Deputy Chair for M348 "Applied Statistical Modelling".

Impact and engagement

I am a member of the GRACE project (Genetics Raising Awareness through Community Engagement) 

Projects

BioDogCom: a Communication System for Bio-Detection Dogs to Inform the Development of Diagnostic Bio-Electronic Sensors to the Open University and Medical Detection Dogs

Grounded in prior research and its promising early findings, this project aims to support the development of a canine bio-detection system for human disease diagnostics, through the funding of a PhD studentship in Artificial Intelligence (AI) applied to Animal-Computer Interaction (ACI). Bio-detection with dogs has significant potential for early disease diagnostics but it also still presents significant limitations. This doctoral project will leverage animal-centred interaction to unlock the potential of bio-detection with dogs, bringing together sensor data sources and machine learning methods to detect, interpret and model the nuances of dogs’ olfactory stimulus response to biological compounds. This will lead to dramatic improvements in the early, non-invasive, safe, fast and inexpensive diagnosis of medical conditions including aggressive cancers, bacteria and viruses, by expediting the development of effective bio-electronic sensors for large-scale diagnostics and by informing strategies for the treatment of aggressive cancers, with a particular focus on colorectal cancer as a case study.

Publications

Book Chapter

Twins and family epigenetic studies of Type 2 Diabetes (2021)

Journal Article

Enhanced resolution profiling in twins reveals differential methylation signatures of type 2 diabetes with links to its complications (2024)

Area-level factors associated with variation in involuntary psychiatric hospitalisation across England: a cross-sectional, ecological study. (2024)

Factors Affecting Students’ Likelihood to Access Feedback (2024)

Stratified genome-wide association analysis of type 2 diabetes reveals subgroups with genetic and environmental heterogeneity (2023)

Accelerated epigenetic aging and DNA methylation alterations in Berardinelli-Seip congenital lipodystrophy (2023)

Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes (2023)

Genetic Impacts on DNA methylation help elucidate regulatory genomic processes (2023)

A faecal metabolite signature of impaired fasting glucose: results from two independent population-based cohorts (2023)

Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome (2023)

Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans (2022)

Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers (2022)

Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects (2021)

Estrogen and COVID-19 symptoms: Associations in women from the COVID Symptom Study (2021)

Bayesian reassessment of the epigenetic architecture of complex traits (2020)