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Dr Daniel Johnson

Lecturer In Health Sciences

School of Life, Health & Chemical Sciences

daniel.johnson@open.ac.uk

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Biography

Professional biography

After working for MSD, I started a PhD entitled 'Enhanced Prediction and Prevention of Torsades de Pointes' at Maastricht University as part of a collaboration with Astrazeneca. I was then a post-doctoral researcher at K.U. Leuven in the laboratory of Prof. Karin Sipido, and obtained my own FWO funding. 

I carried out additional postdocs in the lab of Prof. Gelsomino at Maastricht University in the Department of Cardiothoracic surgery, where I focussed on novel assist devices and atrial fibrillation, and at the University of Birmingham in the groups of Dr Davor Pavlovic and Prof Paulus Kirchhof focussing on the electrophysiology and treatment of atrial fibrillation.

I joined the Open University in January 2020 as a lecturer where i am building up my own research line focussed on both atrial and ventricular arrhythmogenesis and utiling electrophysiological and imaging techniques

Please feel free to get in touch with me if you are thinking about applying for a PhD via the ILESLA scheme (Welcome | ILESLA - Interdisciplinary Life and Environmental Science Landscape Award)

Projects

RIsCa-AF

According to the National Institute of Clinical Excellence, Atrial Fibrillation (AF) is associated with a 46% increase in all-cause mortality. It is the most common heart rhythm disorder with stroke and thromboembolisms being the major complications. Additionally, AF patients have been shown to have a significantly poorer quality of life than healthy controls or the general population (1). This project asks how modifications of a specific cell type in the heart- pulmonary vein myocytes- can influence the occurrence of AF, and how this can be modified by a number of risk factors for AF including biological sex and obesity which have both been shown to be major players in the pathophysiology of this disease (2)

Publications

Journal Article

[Editorial] Emerging molecular mechanisms in cardiovascular physiology and pathology (2024)

Poster Session B (2022)

Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels (2022)

What is actually preserved in HFpEF? Focus on myocyte calcium handling remodelling (2022)

Neurological complications during veno-venous extracorporeal membrane oxygenation: Does the configuration matter? A retrospective analysis of the ELSO database (2021)

Temporal irregularity quantification and mapping of optical action potentials using wave morphology similarity (2020)

Altered adrenergic response in myocytes bordering a chronic myocardial infarction underlies in vivo triggered activity and repolarization instability (2020)

Papillary muscle intervention vs mitral ring annuloplasty in ischemic mitral regurgitation (2020)

In situ skeletonized bilateral thoracic artery for left coronary circulation: a 20-year experience (2020)

Large Dual-Lumen Extracorporeal Membrane Oxygenation Cannulas Are Associated with More Intracranial Hemorrhage (2019)

Lymphadenectomy during pulmonary metastasectomy: Impact on survival and recurrence (2019)

Association between atrial fibrillation and Helicobacter pylori (2019)

Proarrhythmic proclivity of left-stellate ganglion stimulation in a canine model of drug-induced long-QT syndrome type 1 (2019)

High-Throughput Analysis of Optical Mapping Data Using ElectroMap (2019)

Aorto-atrial fistula formation and closure: a systematic review (2019)

Modified Gott shunt to avoid left ventricular overload and cerebral hypoperfusion during distal aortic arch surgery (2019)

Aorto-atrial fistula formation and therapy (2019)

Editorial: The Role of Calcium Handling in Heart Failure and Heart Failure Associated Arrhythmias (2019)

Superior mesenteric and renal flow patterns during intra‐aortic counterpulsation (2019)

Comparison between three different equations for the estimation of glomerular filtration rate in predicting mortality after coronary artery bypass (2019)

Extracellular SPARC increases cardiomyocyte contraction during health and disease (2019)

Continuous monitoring of membrane lung carbon dioxide removal during ECMO: experimental testing of a new volumetric capnometer (2019)

SPARC preserves endothelial glycocalyx integrity, and protects against adverse cardiac inflammation and injury during viral myocarditis (2018)

Open repair of type Ia endoleak in the aortic arch: three tailored approaches (2018)

The Histidine-Rich Calcium Binding Protein in Regulation of Cardiac Rhythmicity (2018)

Deep sternal infections after in situ bilateral internal thoracic artery grafting for left ventricular myocardial revascularization: predictors and influence on 20-year outcomes (2018)

Hyperactive ryanodine receptors in human heart failure and ischaemic cardiomyopathy reside outside of couplons (2018)

Cardiac surgery in adult patients with remitted or active malignancies: a review of preoperative screening, surgical management and short- and long-term postoperative results (2018)

Vascular complications following intra-aortic balloon pump implantation: an updated review (2018)

Arrhythmogenic Mechanisms in Heart Failure: Linking β-Adrenergic Stimulation, Stretch, and Calcium (2018)

[Editorial] Intra-aortic balloon pump: is the tide turning? (2018)

A standardized approach to treat complex aortic valve endocarditis: a case series (2018)

Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant (2017)

Modalities and Effects of Left Ventricle Unloading on Extracorporeal Life support: a Review of the Current Literature (2017)

Calcium/calmodulin-dependent kinase II and nitric oxide synthase 1-dependent modulation of ryanodine receptors during β-adrenergic stimulation is restricted to the dyadic cleft (2016)

Calcium release near l-type calcium channels promotes beat-to-beat variability in ventricular myocytes from the chronic AV block dog (2015)

Interventricular Differences in β‐Adrenergic Responses in the Canine Heart: Role of Phosphodiesterases (2014)

Diastolic Spontaneous Calcium Release From the Sarcoplasmic Reticulum Increases Beat-to-Beat Variability of Repolarization in Canine Ventricular Myocytes After β-Adrenergic Stimulation (2013)

Determinants of Beat-to-Beat Variability of Repolarization Duration in the Canine Ventricular Myocyte: A Computational Analysis (2013)

Drug-induced effects on cardiovascular function in pentobarbital anesthetized guinea-pigs: Invasive LVP measurements versus the QA interval (2012)

Negative electro-mechanical windows are required for drug-induced Torsades de Pointes in the anesthetized guinea pig (2012)

The electro-mechanical window in anaesthetized guinea pigs: a new marker in screening for Torsade de Pointes risk (2012)

Reduced Ventricular Proarrhythmic Potential of the Novel Combined Ion-Channel Blocker AZD1305 Versus Dofetilide in Dogs With Remodeled Hearts (2012)

IKs restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation (2010)

P2X1 Ion Channels Promote Neutrophil Chemotaxis through Rho Kinase Activation (2009)

Functional Mapping of the Transient Receptor Potential Vanilloid 1 Intracellular Binding Site (2006)