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Biography

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I am a Lecturer in Chemistry in the School of Life, Health and Chemical Sciences (LHCS). I am an active researcher in organic chemistry and materials science specialising in organic molecules and materials that produce singlet oxygen (a reactive oxygen species) for use as photosensitizers for the treatment of various cancers using photodynamic therapy. The focus of my research group is to develop functional molecules that can be incorporated into nano- and macro-scale functional materials without loss in activity for the desired function. This would allow for a bottom-up design approach for functional materials and would provide a single component system with tailorable and tuneable physical properties. The over-arching aim is the development of design rules to produce a toolkit of synthetic modifications to convert functional molecules into tailored functional materials via aggregation events.

Prior to joining the Open University in 2023, I spent five years working as a research fellow in Japan on the design and synthesis of novel macrocyclic compounds, singlet oxygen photosensitisers and the design and production of organic functional materials and prior to this was working in contract research for the pharmaceutical industry on the development of synthetic routes towards novel anti-cancer drugs.

PhD Opportunities 

Current PhD opportunities in the School of Life, Health and Chemical Science are advertised here: Current PhD opportunities | Life, Health and Chemical Sciences

If you would be interested to carry out a PhD in my group then please email me for more information. You can also watch the video below by Scott Andrew, a current student in my group, who talks about his research, experiences at the OU and his advice for potential PhD students.

Publications

Book Chapter

On-Surface Translational Activity of Porphyrin Chromophore Molecules (2023)

Journal Article

Design rules for oxoporphyrinogen (‘OxP’) as a versatile chromophore for efficient singlet oxygen generation (2023)

Selective Detection of Toxic C1 Chemicals Using a Hydroxylamine-Based Chemiresistive Sensor Array (2023)

Persistent microporosity of a non-planar porphyrinoid based on multiple supramolecular interactions for nanomechanical sensor applications (2023)

Evaluation of the effects of natural isoquinoline alkaloids on low density lipoprotein receptor (LDLR) and proprotein convertase subtilisin/kexin type 9 (PCSK9) in hepatocytes, as new potential hypocholesterolemic agents (2022)

De novo creation of a naked eye–detectable fluorescent molecule based on quantum chemical computation and machine learning (2022)

Nonionic omnisoluble photosensitizer reference material for the estimation of singlet oxygen quantum yield (2022)

Molecular rotor based on an oxidized resorcinarene (2022)

Photosensitizer Encryption with Aggregation Enhanced Singlet Oxygen Production (2022)

Estimation of Enantiomeric Excess Based on Rapid Host–Guest Exchange (2021)

Enhancement of singlet oxygen generation based on incorporation of oxoporphyrinogen (OxP) into microporous solids (2021)

De Novo Creation of a Naked-Eye-Detectable Fluorescent Molecule Based on Quantum-Chemical Computation and Machine Learning (2021)

Porous framework materials for singlet oxygen generation (2020)

Selective Phase Transfer Reagents (OxP‐crowns) for Chromogenic Detection of Nitrates Especially Ammonium Nitrate (2020)

Enantiomeric Excess Dependent Splitting of NMR Signal through Dynamic Chiral Inversion and Coligand Exchange in a Coordination Complex (2020)

Pushing property limits in materials discovery via boundless objective-free exploration (2020)

Molecular Engineering of β‐Substituted Oxoporphyrinogens for Hydrogen‐Bond Donor Catalysis (2020)

Enantiomeric Excess Dependent Splitting of NMR Signal Through Co-Ligand Dynamic Exchange in a Coordination Complex (2020)

Diporphyrin tweezer for multichannel spectroscopic analysis of enantiomeric excess (2020)

Electron and energy transfer in a porphyrin–oxoporphyrinogen–fullerene triad, ZnP–OxP–C60 (2020)

Supramolecular ultrafast energy and electron transfer in a directly linked BODIPY–oxoporphyrinogen dyad upon fluoride ion binding (2020)

Rotaxanation as a sequestering template to preclude incidental metal insertion in complex oligochromophores (2020)

Nanomolecular singlet oxygen photosensitizers based on hemiquinonoid-resorcinarenes, the fuchsonarenes (2020)

Multimodal switching of a redox-active macrocycle (2019)

Derivatisation of Parthenolide to Address Chemoresistant Chronic Lymphocytic Leukaemia (2019)

Molecular Engineering of β-Substituted Oxoporphyrinogens for Hydrogen-Bond Donor Catalysis (2019)

Knock-on synthesis of tritopic calix[4]pyrrole host for enhanced anion interactions (2019)

Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemia (2019)

Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives (2017)

Rapid Determination of Enantiomeric Excess via NMR Spectroscopy: A Research-Informed Experiment (2017)

Catalysis and Sensing for our Environment (CASE2015) and the Supramolecular Chemistry Ireland Meeting (SCI 2015): Dublin and Maynooth, Ireland. 8th–11th July (2016)

Chiral N,O-Ligand/[Cu(OAc)2]-Catalyzed Asymmetric Construction of 4-Aminopyrrolidine Derivatives by 1,3-Dipolar Cycloaddition of Azomethine Ylides with α-Phthalimidoacrylates (2015)

Chiral N,O-Ligand/[Cu(OAc)2]-Catalyzed Asymmetric Construction of 4-Aminopyrrolidine Derivatives by 1,3-Dipolar Cycloaddition of Azomethine Ylides with α-Phthalimidoacrylates. (2015)

Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants (2015)