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Dr Igor Kraev

Laboratory Manager (EM & Imaging)

Professional Services

igor.kraev@open.ac.uk

ORCID Profile

Biography

Professional biography

I have joined the Open University as the Leverhulme Trust Research Fellow in September 2008 for 1 year. After that I got Postdoctoral Research Associate position in Prof Michael Stewart's lab. Prior to that I was working as a Research Fellow at the Institute of Cell Biophysics (ICB) of  Russian Academy of Sciences (Pushchino, Russia).

Research interests

My main research interests are focused on synaptic plasticity in brain.

  • 3-dimenstional ultrastructural study of effect of stress and learning on synapses in hippocampus region of the brain.
  • Effect of aging on synaptic plasticity in brain.
  • Study of structural interaction between synapses and astroglial processes.
  • Investigation of the role of novel synaptic cell adhesion molecules (CAMs) in memory loss on ultrastructural level.

 

GRANTS, FELLOWSHIPS

  • The Royal Society short visit grant (2007)
  • PENS Summer school travel grant (2007)
  • Russian President grant for young career researchers (2007, for 2 years). Investigation of structural interactions between synapses and astroglia.
  • The Leverhulme Trust Research Fellowship (2008, for 1 year). Investigation of the role of novel synaptic cell adhesion molecules (CAMs) in memory loss on ultrastructural level.
 

Current project

High resolution 3-D reconstructions from brain tissue via Field Emission scanning electron microscopy in back scattered electron (BSE) imaging mode.

Current project is about development of long-time used in our lab 3-dimensional reconstruction method. 

Funded by BBSRC with collaboration with JEOL.

Projects

Publications

Book Chapter

Structure and complexity of the synapse and dendritic spine (2014)

Structure and complexity of the synapse and dendritic spine (2012)

Dendritic spine and synapse morphological alterations induced by a neural cell adhesion molecule mimetic (2010)

Journal Article

Rapid assessment of the osteogenic capacity of hydroxyapatite/aragonite using a murine tibial periosteal ossification model (2025)

Conditioning‐ and reward‐related dendritic and presynaptic plasticity of nucleus accumbens neurons in male and female sign‐tracker rats (2024)

Rescue of synaptosomal glutamate release defects in tau transgenic mice by the tau aggregation inhibitor hydromethylthionine (2024)

Tau‐mediated synaptic dysfunction is coupled with HCN channelopathy (2024)

Low Magnetic Field Exposure Alters Prostate Cancer Cell Properties (2024)

Extracellular vesicles and citrullination signatures are novel biomarkers in sturgeon (Acipenser gueldenstaedtii) during chronic stress due to seasonal temperature challenge (2024)

REST-dependent glioma progression occurs independently of the repression of the long non-coding RNA HAR1A (2024)

Extracellular vesicle signatures and protein citrullination are modified in shore crabs (Carcinus maenus) infected with Hematodinium sp (2023)

A hydrogel model of the human blood-brain barrier using differentiated stem cells (2023)

The Extracellular Vesicle Citrullinome and Signature in a Piglet Model of Neonatal Seizures (2023)

Investigation of the microstructure and phase evolution across multi-material Ni50.83Ti49.17-AISI 316L alloy interface fabricated using laser powder bed fusion (L-PBF) (2022)

Acute Hypoxia Alters Extracellular Vesicle Signatures and the Brain Citrullinome of Naked Mole-Rats (Heterocephalus glaber) (2022)

Extracellular Vesicles Inhibit the Response of Pancreatic Ductal Adenocarcinoma Cells to Gemcitabine and TRAIL Treatment (2022)

Post-translational protein deimination signatures in sea lamprey (Petromyzon marinus) plasma and plasma-extracellular vesicles (2021)

Extracellular Vesicle Signatures and Post-Translational Protein Deimination in Purple Sea Urchin (Strongylocentrotus purpuratus) Coelomic Fluid—Novel Insights into Echinodermata Biology (2021)

Preliminary Investigations Into the Effect of Exercise-Induced Muscle Damage on Systemic Extracellular Vesicle Release in Trained Younger and Older Men (2021)

Age-related ultrastructural neurovascular changes in the female mouse cortex and hippocampus (2021)

Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures (2021)

Attenuation of the extracellular matrix increases the number of synapses but suppresses synaptic plasticity through upregulation of SK channels (2021)

Post-Translational Protein Deimination Signatures in Plasma and Plasma EVs of Reindeer ( Rangifer tarandus ) (2021)

The Proteome and Citrullinome of Hippoglossus hippoglossus Extracellular Vesicles—Novel Insights into Roles of the Serum Secretome in Immune, Gene Regulatory and Metabolic Pathways (2021)

LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia. (2020)

Extracellular vesicles and post-translational protein deimination signatures in haemolymph of the American lobster (Homarus americanus) (2020)

Post-translational protein deimination signatures and extracellular vesicles (EVs) in the Atlantic horseshoe crab (Limulus polyphemus) (2020)

Deimination Protein Profiles in Alligator mississippiensis Reveal Plasma and Extracellular Vesicle-Specific Signatures Relating to Immunity, Metabolic Function, and Gene Regulation (2020)

Extracellular vesicles, deiminated protein cargo and microRNAs are novel serum biomarkers for environmental rearing temperature in Atlantic cod (Gadus morhua L.) (2020)

Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines (2020)

Protein Deimination and Extracellular Vesicle Profiles in Antarctic Seabirds (2020)

Extracellular Vesicles and Post-Translational Protein Deimination Signatures in Mollusca—The Blue Mussel (Mytilus edulis), Soft Shell Clam (Mya arenaria), Eastern Oyster (Crassostrea virginica) and Atlantic Jacknife Clam (Ensis leei) (2020)

Deiminated proteins and extracellular vesicles - novel serum biomarkers in whales and Orca (2020)

Deiminated proteins and extracellular vesicles as novel biomarkers in pinnipeds: Grey seal (Halichoerus gryptus) and harbour seal (Phoca vitulina). (2020)

Protein Deimination Signatures in Plasma and Plasma-EVs and Protein Deimination in the Brain Vasculature in a Rat Model of Pre-Motor Parkinson’s Disease (2020)

Post-Translational Protein Deimination Signatures in Serum and Serum-Extracellular Vesicles of Bos taurus Reveal Immune, Anti-Pathogenic, Anti-Viral, Metabolic and Cancer-Related Pathways for Deimination (2020)

Deiminated proteins in extracellular vesicles and serum of llama (Lama glama)—Novel insights into camelid immunity (2020)

Complement component C4-like protein in Atlantic cod (Gadus morhua L.) - Detection in ontogeny and identification of post-translational deimination in serum and extracellular vesicles (2019)

Post-Translational Deimination of Immunological and Metabolic Protein Markers in Plasma and Extracellular Vesicles of Naked Mole-Rat (Heterocephalus glaber) (2019)

Multi-input Synapses, but Not LTP-Strengthened Synapses, Correlate with Hippocampal Memory Storage in Aged Mice (2019)

Extracellular Vesicles from Cod (Gadus morhua L.) Mucus contain Innate Immune Factors and Deiminated Protein Cargo (2019)

Deiminated proteins in extracellular vesicles and plasma of nurse shark (Ginglymostoma cirratum) - Novel insights into shark immunity (2019)

Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitize Bacteria to Antibiotic Treatment (2019)

Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells (2019)

Cannabidiol Is a Novel Modulator of Bacterial Membrane Vesicles (2019)

Peptidylarginine Deiminases Post-Translationally Deiminate Prohibitin and Modulate Extracellular Vesicle Release and MicroRNAs in Glioblastoma Multiforme. (2019)

Disentangling astroglial physiology with a realistic cell model in silico (2018)

Chronic amphetamine enhances visual input to and suppresses visual output from the superior colliculus in withdrawal (2018)

Repeated intermittent oral amphetamine administration results in locomotor tolerance not sensitization (2018)

Chronic amphetamine treatment affects collicular-dependent behaviour (2018)

Long Term Potentiation (LTP) and Long Term Depression (LTD) Cause Differential Spatial Redistribution of the Synaptic Vesicle Protein Synaptophysin in the Middle Molecular Layer of the Dentate Gyrus in Rat Hippocampus (2016)

Auditory responses in a rodent model of Attention Deficit Hyperactivity Disorder (2015)

Generation of multi-innervated dendritic spines as a novel mechanism of long-term memory formation (2015)

Altered visual processing in a rodent model of Attention-Deficit Hyperactivity Disorder (2015)

Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome (2015)

Dysfunctional Dopaminergic Neurones in Mouse Models of Huntington's Disease: A Role for SK3 Channels (2015)

Glia selectively approach synapses on thin dendritic spines (2014)

Impaired hippocampal Neuroligin-2 Function by chronic stress or synthetic peptide treatment is linked to social deficits and increased aggression (2014)

Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopaty (2014)

Multiple spine boutons are formed after long-lasting LTP in the awake rat (2014)

Forebrain CRF1 modulates early-life stress-programmed cognitive deficits (2011)

A peptide mimetic targeting trans-homophilic NCAM binding sites promotes spatial learning and neural plasticity in the hippocampus (2011)

Suspension of mitotic activity in dentate gyrus of the hibernating ground squirrel (2011)

Alterations in synaptic curvature in the dentate gyrus following induction of long-term potentiation, long-term depression, and treatment with the N-methyl-d-aspartate receptor antagonist CPP (2010)

The N-methyl-d-aspartate receptor antagonist CPP alters synapse and spine structure and impairs long-term potentiation and long-term depression induced morphological plasticity in dentate gyrus of the awake rat (2010)

Three-dimensional ultrastructural and immunohistochemical study of immature neurons in the subgranular zone of the rat dentate gyrus (2009)

Partial kindling induces neurogenesis, activates astrocytes and alters synaptic morphology in the dentate gyrus of freely moving adult rats (2009)

Photon radiation-induced structural and functional changes in the myocardium of hypertensive spontaneously hypertensive rats (2008)

A cell adhesion molecule mimetic, FGL peptide, induces alterations in synapse and dendritic spine structure in the dentate gyrus of aged rats: a three-dimensional ultrastructural study (2008)

Study of nuclear remodeling in reconstructed mouse embryos by optical and electron microscopy (2007)

Protective effect of hypothermia on brain neurons in rats exposed to ionizing radiation (2007)

The effect of hypothermia on the rat radioresistance (2006)

Changes of activity of the protein-synthesizing system of brain neurons of the ground squirrel Citellus undulatus during hibernation and hypothermia (2006)

Effect of ionizing radiation on the protein-synthesizing system of brain neurons of ground squirrels in different functional states (2006)

Chemically induced long-term potentiation increases the number of peforated and complex postsynaptic densities but does not alter dendritic spine volume in CA1 of adult mouse hippocampal slices (2005)

Three-dimensional reconstruction of synapses and dendritic spines in the rat and ground squirrel hippocampus: New structural-functional paradigms for synaptic function (2005)

Stress suppresses and learning induces plasticity in CA3 of rat hippocampus: a three-dimensional ultrastructural study of thorny excrescences and their postsynaptic densities (2005)